NCATS-SM0225

SKU: orb3210166

Description

NCATS-SM0225 is an ER-associated degradation (ERAD) inhibitor and a direct binder of VDAC1, VDAC2, and VDAC3. It has an IC50 of 1.02 μM for ERAD inhibition and a Kd of 3.13 μM for binding to human VDAC1. NCATS-SM0225 disrupts cellular calcium homeostasis, enhances VDAC1-IP3R coupling, and activates PERK. The compound selectively kills cancer cells and has shown tumor growth inhibition in melanoma xenograft models. It is useful for research into various cancers, including melanoma, as well as studies on ERAD and calcium homeostasis regulatory mechanisms.

Key Properties

• CAS Number: 1212623-02-3
• MW: 460.61
• Formula: C₂₃H₂₈N₂O₄S₂
• SMILES: C[C@]12[C@@]([C@@]3([C@@](CC1)([C@H](C)C(=O)O3)[H])[H])([C@H](C)C4=C(C2)SC(NS(CC5=CC=CC=C5)(=O)=O)=N4)[H]
• Target: PERK,VDAC

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

PERK,VDAC