NC-III-49-1

• Catalog Number: orb1982515
• Category: Small Molecules
• Description: NC-III-49-1 is a potent bivalent bromodomain and extraterminal domain (BET) inhibitor with significant affinity for various BRD4 and BRDT isoforms, as demonstrated by its Kd values of 0.095 nM for BRD4-1, 0.32 nM for BRD4-2, 0.29 nM for BRD4-T, 0.089 nM for BRDT-1, 5.5 nM for BRDT-2, and 0.058 nM for BRDT-T. Additionally, NC-III-49-1 exhibits antiproliferative effects and reduces the expression of c-Myc [1].
• Purity: 98.00%
• MW: 875.02
• Biological Activity: NC-III-49-1 is a potent bivalent bromodomain and extraterminal domain (BET) inhibitor with significant affinity for several BRD4 and BRDT isoforms, demonstrated by its Kd values of 0.095 nM for BRD4-1, 0.32 nM for BRD4-2, 0.29 nM for BRD4-T, 0.089 nM for BRDT-1, 5.5 nM for BRDT-2, and 0.058 nM for BRDT-T. Additionally, NC-III-49-1 exhibits antiproliferative effects and reduces the expression of c-Myc [1].
• CAS Number: 3031654-46-0
• Formula: C₄₄H₅₀N₄O₁₁S₂
• SMILES: CN(C1=O)C=C(C2=CC(NS(CC)(=O)=O)=CC=C2OCCOCCOCCOCCOC3=CC=C(NS(CC)(=O)=O)C=C3C(C4=C5C=CC=C4)=CN(C)C5=O)C6=C1C=CC=C6
• Storage: -20°C
• Note: For research use only