NBTI 5463

SKU: orb3134997

Description

NBTI 5463 is a bacterial type II topoisomerase (topoisomerase II) inhibitor with antimicrobial properties. It effectively inhibits GyrA and TopoIV in Pseudomonas aeruginosa and Escherichia coli. By binding to topoisomerase II, NBTI 5463 prevents DNA cleavage and re-ligation, thereby impeding bacterial DNA replication and transcription. This compound shows potential for research into Gram-negative bacterial infections.

Research Area

Infectious Disease & Virology, Molecular Biology

Key Properties

• CAS Number: 1227303-03-8
• MW: 478.54
• Formula: C₂₅H₃₀N₆O₄
• SMILES: C([C@H](N)[C@]1(CC[C@H](NCC=2N=C3C(=CC2)OCC(=O)N3)CC1)[H])N4C=5C(C=CC4=O)=NC=C(OC)C5
• Target: Topoisomerase,Antibacterial

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Topoisomerase,Antibacterial