NBQX disodium salt

SKU: orb1223399

Description

NBQX is an AMPA receptor antagonist. NBQX blocks AMPA receptors in micromolar concentrations (~10–20 μM) and also blocks kainate receptors. In experiments, it is used to counter glutamate excitotoxicity. NBQX was found to have anticonvulsant activity in rodent seizure models. As the disodium salt, NBQX is soluble in water at high concentrations (at least up to 100 mM).(In Vitro):NBQX (FG9202) has a high affinity for AMPA and kainate binding sites with little or no affinity for the glutamate recognition site on the NMDA receptor complex.(In Vivo):NBQX (FG9202; 20 mg/kg, i.p.; for 3 days) decreases seizures induced by PTZ.NBQX is neuroprotective in a focal ischaemia model in the rat when given as an i.v. bolus dose of 30 mg/kg at the time of MCA occlusion and again at 1 h post occlusion.

Key Properties

• CAS Number: 118876-58-7
• MW: 336.28
• Purity: >98% (HPLC)
• Formula: C₁₂H₈N₄O₆S
• SMILES: c1cc2c3c(cc(c2c(c1)S(=O)(=O)N)[N+](=O)[O-])[nH]c(=O)c(=O)[nH]3
• Target: PAR
• Solubility: DMSO : ≥ 75 mg/mL. 223.03 mM; H2O : < 0.1 mg/mL

Bioactivity

• In Vivo:
  Animal model: Male Wistar rats that weighed 220-240 g with pentylenetetrazole (PTZ). Dosage: 20 mg/kg. Administration: IP; for 3 days. Result: Effectively reversed the behavioral abnormality of epileptic seizures of chronic PTZ administration (50 mg/kg; i.p.; for 28 days) in rats.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

NBQX

Quick Database Links

Gene Symbol

PAR