NB-598

SKU: orb1296193

Description

NB-598

Research Area

Immunology & Inflammation, Infectious Disease & Virology, Neuroscience

Key Properties

• CAS Number: 131060-14-5
• MW: 449.67
• Purity: 99.40% (May vary between batches)
• Formula: C₂₇H₃₁NOS₂
• SMILES: CCN(C\C=C\C#CC(C)(C)C)Cc1cccc(OCc2cc(cs2)-c2ccsc2)c1
• Target: Others,Antifungal,COX
• Solubility: 10% DMSO+90% Corn Oil:1 mg/mL (2.22 mM);DMSO:10 mg/mL (22.24 mM)

Bioactivity

• In Vitro:
  NB-598 (10 μM) inhibits the synthesis of sterol and sterol ester from [14C]acetate without affecting the synthesis of other lipids such as phospholipids (PL), free fatty acids (FFA) and triacylglycerol (TG). In the absence of exogenous liposomal cholesterol, NB-598 reduces ACAT activity by 31%. NB-598 reduces ACAT activity by 22% even in the presence of a 600 pM concentration of liposomal cholesterol . NB598 (10 μM) causes a 36±7% reduction in the total cholesterol level of MIN6 cells. NB598 causes a significant decrease in cholesterol by 49±2%, 46±7%, and 48±2% from PM, ER, and SG, respectively. NB598 dose-dependently inhibits insulin secretion under both basal (1 mM glucose) and glucose-stimulated (16.7 mM glucose) conditions. NB598 at concentrations up to 10 μM does not affect peak outward KV currents or the voltage dependence of activation but increases current inactivation .
  Read more...

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, NB598, NB-598, NB 598, Inhibitor, Squalene epoxidase

Compound Identifiers

PubChem CID

6443223