Nazartinib mesylate

SKU: orb1709795

Description

Nazartinib mesylate is a covalent, mutant-selective EGFR inhibitor targeting the L858R/T790M mutant with a Ki of 31 nM and a Kinact of 0.222/min. It is a research tool for studying resistance mechanisms in non-small cell lung cancer (NSCLC) and has demonstrated antitumor activity in both cellular assays and in vivo models.

Research Area

Cardiovascular Research, Signal Transduction

Key Properties

• CAS Number: 1508250-72-3
• MW: 591.12
• Formula: C₂₇H₃₅ClN₆O₅S
• SMILES: S(C)(=O)(=O)O.N(C(=O)C=1C=C(C)N=CC1)C=2N(C=3C(N2)=CC=CC3Cl)[C@]4(CN(C(/C=C/CN(C)C)=O)CCCC4)[H]
• Target: EGFR,Others

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

91809207