Nav1.8-IN-1

SKU: orb1298815

Description

Nav1.8-IN-1 is a selective small molecule inhibitor of the human voltage-gated sodium channel NaV1.8 (SCN10A). This compound is a valuable research tool for investigating NaV1.8's role in pain signaling and is suitable for both in vitro electrophysiology studies and in vivo preclinical models of neuropathic and inflammatory pain.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1026822-49-0
• MW: 421.8
• Purity: 97.59% (May vary between batches)
• Formula: C₂₀H₁₅ClF₃N₃O₂
• SMILES: C(NCC1=C(OCC(F)(F)F)N=CC=C1)(=O)C2=CC(=CN=C2)C3=CC=C(Cl)C=C3
• Target: Sodium Channel
• Solubility: DMSO:10 mg/mL (23.71 mM)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, Nav1.8 channel, Nav1.8 IN 1, Nav1.8IN1, Nav1.8-IN-1, neuropathic pain, Na channels, Na+ channels, Na(v)1.8, inhibit, inflammatory, 5-(4-Chlorophenyl)-N-[[2-(2,2,2-trifluoroethoxy)pyridin-3-yl]methyl]pyridine-3-carboxamide, CHEMBL1270208, CHEMBL-1270208, CHEMBL 1270208, Sodium Channel, SodiumChannel

Compound Identifiers

PubChem CID

16040329