Nauclefine

SKU: orb1680621

Description

Nauclefine (Parvine) is a natural indole alkaloid that triggers apoptosis in various cancer cells through a PDE3A-SLFN12-dependent mechanism, despite binding to PDE3A without inhibiting its enzymatic activity. It serves as a valuable research tool for studying this novel cell death pathway in both in vitro and in vivo oncology models.

Research Area

Cell Biology, Metabolism Research

Key Properties

• CAS Number: 57103-51-2
• MW: 287.32
• Purity: 99.92% (May vary between batches)
• Formula: C₁₈H₁₃N₃O
• SMILES: O=C1N2C(C3=C(C=4C(N3)=CC=CC4)CC2)=CC=5C1=CN=CC5
• Target: Apoptosis,PDE
• Solubility: DMSO:20 mg/mL (69.61 mM)

Bioactivity

• In Vivo:
  Nauclefine inhibits tumor xenograft growth in vivo, doing so in a PDE3A- and SLFN12-dependent manner.

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Parvine, PDE3A, Nauclefine

Compound Identifiers

PubChem CID

320217