Naringenin

SKU: orb1304953

Description

Naringenin is a bioactive flavanone with antioxidant, anti-inflammatory, and immunomodulatory properties. It has been studied in vitro and in vivo for its roles in promoting carbohydrate metabolism, scavenging free radicals, and supporting DNA repair mechanisms.

Research Area

Immunology & Inflammation, Infectious Disease & Virology, Metabolism Research, Molecular Biology, Signal Transduction

Key Properties

• CAS Number: 480-41-1
• MW: 272.25
• Purity: 99.55% (May vary between batches)
• Formula: C₁₅H₁₂O₅
• SMILES: O=C1C=2C(O[C@@H](C1)C3=CC=C(O)C=C3)=CC(O)=CC2O
• Target: Cytochromes P450,Influenza Virus,Reactive Oxygen Species,Anti-infection,ROS,Endogenous Metabolite,PPAR
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (14.69 mM);DMSO:100 mg/mL (367.31 mM);Ethanol:5 mg/mL (18.37 mM);H2O:< 1 mg/mL (insoluble or slightly soluble)

Bioactivity

• In Vivo:
  Naringenin, found in grapefruit juice, has been demonstrated to inhibit the human cytochrome P450 isoform CYP1A2. This can adversely alter the pharmacokinetics of several common agents in human (or directly homologous) hosts, potentially rendering otherwise harmless substances carcinogenic.
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• In Vitro:
  In both normoglycemic and non-insulin-dependent diabetes mellitus rat models, oral administration of 50 mg/kg Naringenin resulted in a significant decrease in plasma glucose levels.
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• Cell Research:
  Naringenin is dissolved in DMSO and diluted in cell culture medium. The cells are rinsed with PBS and grown in a medium containing various concentrations of naringenin (50, 100, 150, 200, 250, 300 μM). The solvent DMSO treated cells are served as control. After 24 hrs of treatment, the medium is removed and replaced by another medium containing MTT. Cell viability is measured using the MTT assay.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

EndogenousMetabolite, CYP1A2, Endogenous Metabolite, Naringenin, Naringetol, NSC11855, NSC-11855, NSC 34875, NSC 11855, NSC34875, NSC-34875, InfluenzaVirus, Influenza Virus, PPAR, Pelargidanon, Reactive Oxygen Species, ReactiveOxygenSpecies, Salipurol, S-Dihydrogenistein

Compound Identifiers

PubChem CID

439246