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Catalog Number | orb1300624 |
---|---|
Category | Small Molecules |
Description | Naratriptan hydrochloride |
Purity | 99.89% |
MW | 371.93 |
Biological Activity | Naratriptan Hydrochloride is the hydrochloride salt form of naratriptan, a sulfonamide with selective serotonin (5-HT) 1 receptor agonistic activity and anti-migraine property. Naratriptan hydrochloride (GR-85548A hydrochloride) binds selectively and with high affinity to the 5-HT1D and 5-HT1B receptor subtypes. Activation of these 5-HT1D/B receptors located on intracranial blood vessels leads to vasoconstriction and provides relief of migraine headaches. Naratriptan hydrochloride may also exerts its effect by stimulation of 5-HT1D/1B receptors on sensory nerve endings in the trigeminal system thereby decreasing the release of pro-inflammatory neuropeptides. |
CAS Number | [143388-64-1] |
Formula | C17H25N3O2S·HCl |
SMILES | Cl.CNS(=O)(=O)CCc1ccc2[nH]cc(C3CCN(C)CC3)c2c1 |
Storage | -20°C |
Note | For research use only |
> 98% (HPLC) | |
143388-64-1 | |
371.9 | |
C17H25N3O2S·HCl |