Naproxcinod

SKU: orb1695959

Description

Naproxcinod is a CINOD (COX-inhibitory nitric oxide donor) derived from naproxen, designed to provide analgesic and anti-inflammatory effects for conditions like osteoarthritis. Research applications include investigating its nitric oxide-mediated gastroprotective potential and COX inhibition in both in vitro enzyme assays and in vivo inflammatory pain models.

Research Area

Immunology & Inflammation, Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 163133-43-5
• MW: 347.36
• Purity: 99.85% (May vary between batches)
• Formula: C₁₈H₂₁NO₆
• SMILES: [O-][N+](OCCCCOC([C@H](C1=CC2=C(C=C1)C=C(C=C2)OC)C)=O)=O
• Target: Immunology/Inflammation related,COX,NO Synthase

Bioactivity

• In Vivo:
  Naproxcinod (0, 10, 21, and 41 mg/kg, orally administered once daily for 42 weeks) significantly increased average body weight (+7.3%) compared to the solvent control group and improved skeletal and cardiac disease phenotypes in DMD mice .
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• In Vitro:
  Naproxcinod (1-30 μM, 15 minutes) increased cGMP levels in a concentration-dependent manner, reaching up to 27 times the baseline level . Naproxcinod (1-100 μM, 8 hours) enhanced HO-1 mRNA expression in endothelial cells in a concentration-dependent manner .
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

AZD 3582, AZD3582, AZD-3582, Naproxen-N-butyl Nitrate, Naproxen-N-butyl nitrate, Naproxcinod, Nitronaproxen, HCT3012, HCT-3012, HCT 3012

Compound Identifiers

PubChem CID

9884642