Naphthol AS-MX phosphate

SKU: orb3134372

Description

Naphthol AS-MX phosphate (NASTRp) is a small-molecule inhibitor targeting the CREB (cyclic adenosine monophosphate response element-binding protein)-CBP (CREB-binding protein) transcription factor complex. It exhibits antitumor activity against lung cancer cells by inhibiting tumor cell proliferation (IC50=3.701 μmol/L), colony formation, and anchorage-independent growth in soft agar. This compound is valuable for studying KRAS-mutant lung cancer, particularly in cases of chemotherapy resistance and poor prognosis.

Research Area

Epigenetics & Chromatin

Images & Validation

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Key Properties

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CAS Number	1596-56-1
MW	371.32
Formula	C₁₉H₁₈NO₅P
SMILES	O=C(NC1=CC=C(C=C1C)C)C2=CC=3C=CC=CC3C=C2OP(=O)(O)O
Target	Epigenetic Reader Domain

Storage & Handling

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Storage	-20°C
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

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Quick Database Links

Gene Symbol

Epigenetic Reader Domain

Protocol Information

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