Naperiglipron

SKU: orb3173280

Description

Naperiglipron (LY3549492) (Example 2) is a glucagon-like peptide-1 receptor (GLP-1R) agonist with an EC50 of 1.14 nM for hGLP-1R. It markedly reduces blood glucose levels in GLP-1R gene knock-in mouse models. Additionally, Naperiglipron inhibits PDE10A1 enzyme activity (IC50: 7.43 μM) and exhibits weak hERG inhibitory activity. This compound is applicable in research on Type II diabetes mellitus (T2DM) and obesity.

Research Area

Metabolism Research, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 2572566-11-9
• MW: 580.59
• Formula: C₃₃H₂₆F₂N₄O₄
• SMILES: C(N1C=2C(N=C1CC3=C(F)C=C(C(C)=C3)C=4N=C(OCC5=C(F)C=C(C#N)C=C5)C=CC4)=CC=C(C(O)=O)C2)[C@@H]6CCO6
• Target: Glucagon Receptor,PDE

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Glucagon Receptor,PDE