Nanchangmycin

SKU: orb1224343

Description

A polyether ionophore antibiotic isolated from Streptomyces nanchangensis NS3226 that shows antibacterial and antiviral properties; A potent inhibitor of Zika virus entry, also is active against other medically relevant viruses, including West Nile, dengue, and chikungunya viruses.

Key Properties

• CAS Number: 65101-87-3
• MW: 889.0956
• Purity: >98% (HPLC)
• Formula: C₄₇H₇₇NaO₁₄
• SMILES: C[C@H]([C@@H](O1)[C@H](C)[C@@H](O)C[C@@]21CC[C@@](C)([C@@H](C[C@H](OC3O[C@H](C)[C@@H](OC)CC3)[C@H]4C)O[C@]54[C@@H](C)C[C@H]([C@H]6O[C@](CO)(O)[C@H](C)C[C@@H]6C)O5)O2)/C=C(C)/C([C@H](C)C[C@H](C)C([O-])=O)=O.[Na+]
• Target: Antibacterial
• Solubility: DMSO: ≥ 26 mg/mL

Bioactivity

• In Vitro:
  Nanchangmycin can be used as a growth promotant in poultry and to cure coccidiosis in chickens. Nanchangmycin is active against drug resistant strains of malaria. Nanchangmycin as a potent inhibitor of Zika virus (ZIKV) entry across all cell types tested including physiologically relevant primary cells. Nanchangmycin potently reduces infection of all three strains of ZIKV across all three cell types. The IC50s for infection are between 0.1 and 0.4 μM while Nanchangmycin has low toxicity in these ranges. In addition, DENV is inhibited by Nanchangmycin across cell types.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Nanchangmycin A

Quick Database Links

Gene Symbol

Antibacterial