Nanatinostat

SKU: orb1706928

Description

Nanatinostat

Research Area

Cell Biology, Epigenetics & Chromatin, Molecular Biology

Key Properties

• CAS Number: 1256448-47-1
• MW: 394.4
• Purity: 99.03% (May vary between batches)
• Formula: C₂₀H₁₉FN₆O₂
• SMILES: N(CC1=NC2=C(C=C1)C=C(F)C=C2)[C@H]3[C@]4([C@@]3(CN(C4)C=5N=CC(C(NO)=O)=CN5)[H])[H]
• Target: HDAC,Apoptosis
• Solubility: DMSO:40 mg/mL (101.42 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.07 mM)

Bioactivity

• Target IC50:
  HDAC3:7 nM|HDAC6:2100 nM|HDAC2:4 nM|HDAC1:3 nM|HDAC5:200 nM|HDAC:8 nM
• In Vivo:
  Methods: H929, KMS11, LP-1, MM1-S, and RPMI-8828 cells were treated with Nanatinostat (CHR-3996) (0.0001-100 μM), and cell proliferation was detected by WST-1. Results: The LC50 values ​​of various cell lines treated with Nanatinostat ranged from 30.3-97.6 nM.
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• In Vitro:
  Methods: Nanatinostat (CHR-3996) (30 mg/kg, oral) was used to treat NOD/SCID mice that were inoculated subcutaneously with 2×10^6 H929 myeloma cells on the right flank. Caliper measurements of the longest vertical tumor diameter (length) and width were performed every other day. Results: Nanatinostat slowed tumor growth in tumor-bearing mice.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CHR3996, CHR-3996, CHR 3996, Nanatinostat, HDAC

Compound Identifiers

PubChem CID

49857317