NAMPT inhibitor-linker 2

SKU: orb1987908

Description

NAMPT inhibitor-linker 2, a drug-linker conjugate for antibody-drug conjugates (ADCs), comprises an NAMPT inhibitor payload and a linker. When combined with an anti-c-Kit monoclonal antibody to form ADC-4, it demonstrates potent efficacy against c-Kit expressing cell lines, including GIST-T1 and NCI-H526, with IC50 values of <7 pM and 40 pM, respectively.

Key Properties

• CAS Number: 2241014-82-2
• MW: 624.66
• Formula: C₃₄H₃₃FN₆O₅
• SMILES: C(NC1=CC(F)=C(CNC(=O)C2=CC=C(C=C2)N3CCN(C(CCN4C(=O)C=CC4=O)=O)CC3)C=C1)(=O)[C@@H]5[C@H](C5)C=6C=CC=NC6
• Target: Drug-Linker Conjugates for ADC,NAMPT

Storage & Handling

• Storage: -20°C
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Drug-Linker Conjugates for ADC,NAMPT