Nampt-IN-17

SKU: orb3210472

Description

Nampt-IN-17 is an orally active selective NAMPT inhibitor with an IC50 of 17 nM and a Ki of 25.9 nM for human NAMPT. It depletes intracellular NAD+ and ATP, disrupts mitochondrial membrane potential, inhibits cell proliferation, self-renewal, invasion, and migration, and induces cell cycle arrest and apoptosis (apoptosis). Nampt-IN-17 exhibits selective activity against NAPRT-deficient gastric cancer cells and is suitable for research related to NAPRT-deficient gastric cancer.

Key Properties

• CAS Number: 3077970-78-3
• MW: 461.53
• Formula: C₂₆H₂₈FN₅O₂
• SMILES: C(N[C@@H](C)C1=CC=C(NC(NCC=2C=CC=NC2)=O)C=C1)(=O)C3=C(C=CC(F)=C3)N4CCCC4
• Target: NAMPT,Apoptosis

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

NAMPT,Apoptosis