Nampt activator-2

SKU: orb1744787

Description

Nampt activator-2 is a potent small molecule activator of NAMPT (EC50 = 23 nM) with demonstrated binding affinity for cytochrome P450 isoforms 2C9, 2D6, and 2C19. It serves as a valuable research tool for investigating metabolic diseases, including atherosclerosis, obesity, and diabetes, in both cellular and animal models.

Research Area

Metabolism Research

Key Properties

• CAS Number: 2237268-90-3
• MW: 390.84
• Purity: 98.88% (May vary between batches)
• Formula: C₁₇H₁₅ClN₄O₃S
• SMILES: S(=O)(=O)(C1=CC=C(NC(NCC=2C=NNC2)=O)C=C1)C3=CC=C(Cl)C=C3
• Target: Cytochromes P450,NAMPT
• Solubility: DMSO:100 mg/mL (255.86 mM)

Bioactivity

• Target IC50:
  NAMPT:0.023 μM(EC50)
• In Vivo:
  Nampt activator-2 (compound 34) (1 mg/kg IV; 10 mg/kg PO; once) demonstrates low plasma clearance, substantial exposure, and excellent oral bioavailability (%F = 80).
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• In Vitro:
  Nampt activator-2 (compound 34) (10 μM; 4 h) significantly increases NMN and NAD levels in A549 lung epithelial cells.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CYP2C9, CYP2C19, NAMPT

Compound Identifiers

PubChem CID

135223401