NAE-IN-3

SKU: orb3174295

Description

NAE-IN-3 (compound 1) is a potent and highly selective non-covalent competitive inhibitor of NEDD8-activating enzyme (NAE) with an IC50 of 0.8 μM. It inhibits NAE by blocking the ATP binding site and demonstrates selectivity over related E1 enzymes UAE and SAE. NAE-IN-3 is applicable for cancer research.

Research Area

Metabolism Research

Key Properties

• CAS Number: 951950-33-7
• MW: 374.35
• Formula: C₁₇H₁₈N₄O₆
• SMILES: O=C(O)CNC(=O)CNC(=O)COC=1C=CC=2N=C3N(C(=O)C2C1)CCC3
• Target: NEDD8

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

NEDD8