NADPH tetrasodium salt

SKU: orb1220605

Description

NADPH tetrasodium salt is the reduced form of the electron acceptor nicotinamide adenine dinucleotide phosphate (NADP+) and acts as an electron donor in various biological reactions.

Key Properties

• CAS Number: 2646-71-1
• MW: 833.35
• Purity: >98% (HPLC)
• Formula: C₂₁H₂₆N₇Na₄O₁₇P₃
• SMILES: [Na+].[Na+].[Na+].[Na+].NC(=O)C1=CN(C=CC1)C1OC(COP([O-])(=O)OP([O-])(=O)OCC2OC(C(OP([O-])([O-])=O)C2O)n2cnc3c(N)ncnc23)C(O)C1O
• Target: Others
• Solubility: H2O:35 mg/mL (42.00 mM)

Bioactivity

• In Vitro:
  NADPH tetrasodium salt de novo synthesis is catalyzed by NAD kinases (NADKs), which catalyze the phosphorylation of NAD+ to form NADP+. NADPH tetrasodium salt is mainly involved in catabolic reactions, whereas NADPH tetrasodium salt is primarily involved in cellular antioxidative effects and anabolic reactions. NADPH tetrasodium salt is used by glutathione reductase (GR) to reduce oxidized glutathione (GSSG) to GSH. The regeneration rate of NADPH tetrasodium salt is often the rate-limiting step for the over-production of desired chemicals, while maintaining robust cellular growth. NADPH tetrasodium salt homeostasis is regulated by varied signaling pathways and several metabolic enzymes that undergo adaptive alteration in cancer cells. The metabolic reprogramming of NADPH tetrasodium salt renders cancer cells both highly dependent on this metabolic network for antioxidant capacity and more susceptible to oxidative stress. NADPH tetrasodium salt is an essential intracellular reductant needed to eliminate lipid hydroperoxides. Indeed, NADPH tetrasodium salt levels are a biomarker of ferroptosis sensitivity across many cancer cell lines.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

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