NADH disodium salt hydrate

SKU: orb1221146

Description

NADH is the reduced form of nicotinamide adenine dinucleotide (NAD) that can donate electrons as part of a reducing reaction. In that process NADH becomes oxidized to produce NAD+. A variety of enzymes use NADH plus H+ to reduce substrates generating NAD+ as well as the reduced product.

Key Properties

• CAS Number: 606-68-8
• MW: 709.4
• Purity: >98% (HPLC)
• Formula: C₂₁H₂₇N₇Na₂O₁₄P₂
• SMILES: [Na+].[Na+].NC(=O)C1=CN(C=CC1)[C@@H]1O[C@H](COP([O-])(=O)OP([O-])(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)n2cnc3c(N)ncnc23)[C@@H](O)[C@H]1O
• Target: Others
• Solubility: DMSO:42.3 mM

Bioactivity

• In Vivo:
  Animal model: Male ICR mice. Dosage: 5 μmol/mouse. Administration: Intraperitoneal injection or oral administration, once. Result: Produced significant increases in urinary excretions of nicotinamide (Nam) with intraperitoneal injection. Oral administration did not produce any increases in Nam or its metabolites. Animal model: Male C57BL/6J mice. Dosage: 500 mg/kg. Administration: Intragastric administration, 15 min before ethanol administration. Result: Significantly increased blood acetaldehyde levels in mice administered with alcohol between 30 min and two hours. Significantly reduced the acetaldehyde in the blood after two hours. Inhibited the decrease of NAD+/NADH redox ratio in hepatocytes.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Disodium NADH | NADH disodium salt

Quick Database Links

Gene Symbol

Others