NAB815

SKU: orb3142667

Description

NAB815 is a specific inhibitor of Stx2a (Kd= 0.01 μM)/TLR4 interactions. It inhibits the interaction between neutrophils and Stx2a with an IC50 of 0.057 μg/mL. NAB815 also prevents the formation of extracellular vesicles (EV) containing Stx2 from leukocytes and platelets, reducing its toxicity in cells (Vero cells) and in animal models (CD-1 mice). Additionally, NAB815 decreases the bacterial load in the kidneys, urine, and bladder of mice infected with Escherichia coli. It is applicable for research in hemolytic uremic syndrome (HUS).

Research Area

Immunology & Inflammation, Infectious Disease & Virology

Key Properties

• Target: Antibacterial,TLR
• CAS Number: 1969250-99-4
• MW: 1175.42
• Formula: C₅₅H₉₄N₁₄O₁₄
• SMILES: C([C@@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC)C(=O)N[C@@H](CCN)C(=O)N[C@@]([C@@H](C)O)(C(=O)NCC[C@H](NC([C@H](NC([C@@H](NC([C@@H](NC(CCCCCCC)=O)CCN)=O)[C@@H](C)O)=O)[C@H](C)O)=O)C(=O)N[C@@H](CCN)C(=O)N1)[H])C2=CC=CC=C2

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Antibacterial,TLR