NA-Ir

SKU: orb2665028

Description

NA-Ir is a ferroptosis inducer that targets mitochondrial DNA to activate the cGAS-STING pathway and promote ferritinophagy. Its photodynamic activity enhances ROS production, depletes GSH, and downregulates GPX4 to drive lipid peroxidation. This compound shows selective activity against cancer cells with elevated H2S levels in both cellular and animal studies.

Research Area

Cell Biology, Immunology & Inflammation, Metabolism Research

Key Properties

• CAS Number: 3031762-97-4
• MW: 1138.04
• Formula: C₄₉H₃₆F₆IrN₈O₄P
• SMILES: F[P-](F)(F)(F)(F)F.[N-]=[N+]=NC1=CC=C2C(N(CCC(OCC3=CC(C4=CC(C)=CC=[N]4[Ir+3]567([C-]8=C(C9=[N]7C=CC=C9)C=CC=C8)[C-]%10=C(C%11=[N]6C=CC=C%11)C=CC=C%10)=[N]5C=C3)=O)C(C%12=CC=CC1=C%122)=O)=O
• Target: Ferroptosis|||Mitochondrial Metabolism|||STING|||Autophagy

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Ferroptosis|||Mitochondrial Metabolism|||STING|||Autophagy