N6-methyladenosine

SKU: orb1300626

Description

N6-Methyladenosine (m6A) is the most abundant internal modification in eukaryotic messenger RNA and can also be found on viral RNA, influencing viral activity. This endogenous nucleoside, derived from tRNA degradation, is a critical small molecule for studying epitranscriptomics in both in vitro and in vivo models to investigate gene expression and host-pathogen interactions.

Research Area

Infectious Disease & Virology, Metabolism Research

Key Properties

• CAS Number: 1867-73-8
• MW: 281.27
• Purity: 99.66% (May vary between batches)
• Formula: C₁₁H₁₅N₅O₄
• SMILES: O[C@H]1[C@H](N2C=3C(N=C2)=C(NC)N=CN3)O[C@H](CO)[C@H]1O
• Target: Influenza Virus,Endogenous Metabolite
• Solubility: DMSO:126 mg/mL (447.97 mM);Ethanol:2 mg/mL (7.11 mM);H2O:14 mg/mL (49.77 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (14.22 mM)

Bioactivity

• In Vivo:
  LD50: Mice >1 g/kg (i.g.).
• In Vitro:
  N6-Methyladenosine is an abundant modification in mRNA and is found within some viruses, and most eukaryotes including mammals, insects, plants and yeast. It is also found in tRNA, rRNA, and small nuclear RNA(snRNA) as well as several long non-coding RNA, such as Xist. N6-Methyladenosine is an endogenous urinary nucleoside product of the degradation of transfer ribonucleic acid (tRNA). N6-Methyladenosine is a widespread RNA modification in many tissues with high levels in the brain. N6-Methyladenosine is enriched near stop codons and within 3'UTRs in both mouse and human mRNAs. The recent discovery that FTO, an obesity risk gene, encodes an m6A demethylase implicates m6A as an important regulator of physiological processes.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Endogenous Metabolite, EndogenousMetabolite, NSC29409, NSC-29409, m6A, N-Methyladenosine, N6 methyladenosine, N6methyladenosine, N-6-methyladenosine, NSC 29409, Influenza Virus, InfluenzaVirus, 6-Methyladenosine

Compound Identifiers

PubChem CID

102175