N6-methyladenosine

SKU: orb1225847

Description

N6-methyl adenosine (N6-methyl ATP) is a base modified analog of adenosine and is found as a minor nucleoside in natural Rnas.

Key Properties

• CAS Number: 1867-73-8
• MW: 281.27
• Purity: >98% (HPLC)
• Formula: C₁₁H₁₅N₅O₄
• SMILES: CNC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O |r,c:4,6,9,t:2|
• Target: Others
• Solubility: DMSO:56 mg/mL (199.09 mM); Ethanol:2 mg/mL (7.11 mM); Water:14 mg/mL (49.77 mM)

Bioactivity

• In Vitro:
  N6-methyladenosine (m6A) is selectively recognized by the human YTH domain family 2 (YTHDF2) protein to regulate mRNA degradation. N6-methyladenosine (m6A), a prevalent internal modification in the messenger RNA of all eukaryotes, is post-transcriptionally installed by m6A methyltransferase (e. g., MT-A70) within the consensus sequence of G(m6A)C (70%) or A(m6A)C (30%). N6-methyladenosine (m6A)-containing RNAs are greatly enriched in the YTHDF-bound portion and diminished in the flow-through portion. N6-methyladenosine (m6A), the most abundant internal RNA modification, functions in diverse biological processes, including regulation of embryonic stem cell self-renewal and differentiation. N6-methyladenosine (m6A) is a large protein complex, consisting in part of methyltransferase-like 3 (METTL3) and methyltransferase-like 14 (METTL14) catalytic subunits.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

(m6A)

Quick Database Links

Gene Symbol

Others