N-piperidine Ibrutinib hydrochloride

SKU: orb2901779

Description

N-piperidine Ibrutinib hydrochloride (Compound 1) is a reversible Ibrutinib derivative. N-piperidine Ibrutinib hydrochloride is a potent BTK inhibitor with IC50s of 51.0 and 30.7 nM for WT BTK and C481S BTK, respectively. N-piperidine Ibrutinib hydrochloride can be used as a BTK ligand in the synthesis of a series of PROTACs, such as SJF620 (HY-133137). SJF620 is a potent PROTAC BTK degrader with a DC50 of 7.9 nM.

Research Area

Pharmacology & Drug Discovery

Images & Validation

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Key Properties

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CAS Number	2231747-18-3
MW	422.91
Purity	>98% (HPLC)
Formula	C₂₂H₂₃ClN₆O
SMILES	Cl.Nc1ncnc2n(nc(-c3ccc(Oc4ccccc4)cc3)c12)C1CCNCC1
Target	BTK
Solubility	In Vitro: DMSO : 100 mg/mL (236.46 mM; Ultrasonic ) H2O : 50 mg/mL (118.23 mM; Ultrasonic)

Storage & Handling

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Storage	Storage temperature: -20°C. Stability: ≥ 2 years
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

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Quick Database Links

Gene Symbol

BTK

Protocol Information

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