N-Oleoyl glycine

SKU: orb1308785

Description

N-Oleoyl glycine

Research Area

Metabolism Research, Molecular Biology, Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 2601-90-3
• MW: 339.51
• Purity: 97.43% (May vary between batches)
• Formula: C₂₀H₃₇NO₃
• SMILES: CCCCCCCC\C=C/CCCCCCCC(=O)NCC(O)=O
• Target: Cannabinoid Receptor,Akt,Endogenous Metabolite,PPAR
• Solubility: DMSO:80 mg/mL (235.63 mM);10% DMSO+90% Corn Oil:3.3 mg/mL (9.72 mM)

Bioactivity

• In Vitro:
  N-Oleoyl glycine stimulated lipid accumulation and significantly increased adipogenic genes (PPARγ and aP2), in a dose- and time-dependent manner. Additionally, N-Oleoyl glycine markedly increased the mRNA expression of CB1 receptor and the inhibition of CB1R by its antagonist SR141716 abolished the promotive effects of N-Oleoyl glycine on lipid accumulation and the protein expression of PPARγ and aP2. Furthermore, N-Oleoyl glycine increased the ratio of p-Akt/Akt and p-FoxO1/FoxO1, which could be reversed by SR141716. Moreover, N-Oleoyl glycine-induced enhancement of adipogenesis, activation of insulin-mediated Akt signaling pathway and inactivation of FoxO1 were effectively blocked by Wortmannin, a specific PI3K/Akt inhibitor, indicating the essential role of Akt signaling pathway in the process of N-Oleoyl glycine-stimulated 3T3-L1 adipogenesis.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Protein kinase B, PKB, PPARγ, CB1, Akt, Cannabinoid Receptor, CannabinoidReceptor, Inhibitor, NOleoyl glycine, N-Oleoyl glycine, inhibit, N Oleoyl glycine, Human Endogenous Metabolite, EndogenousMetabolite, Endogenous Metabolite

Compound Identifiers

PubChem CID

6436908