N-desmethyl Regorafenib N-oxide

SKU: orb2283281

Description

N-Desmethyl Regorafenib N-oxide is a pharmacologically active metabolite of regorafenib, formed via CYP3A4 metabolism. It potently inhibits kinases including VEGFR2 and B-RAF in vitro and demonstrates in vivo antitumor efficacy in xenograft models, such as HT-29 and MDA-MB-231, at low doses.

Research Area

Cardiovascular Research, Metabolism Research, Signal Transduction

Key Properties

• CAS Number: 835621-12-0
• MW: 484.79
• Formula: C₂₀H₁₃ClF₄N₄O₄
• SMILES: O(C=1C=C(C(N)=O)N(=O)=CC1)C2=CC(F)=C(NC(NC3=CC(C(F)(F)F)=C(Cl)C=C3)=O)C=C2
• Target: Drug Metabolite,VEGFR,Raf,Others,c-Kit

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Drug Metabolite,VEGFR,Raf,Others,c-Kit