N-Desmethyl imatinib

SKU: orb1309548

Description

N-Desmethyl imatinib is the primary active metabolite of the tyrosine kinase inhibitor Imatinib. It retains activity against targets such as c-Kit, Abl, and PDGFR, making it a relevant compound for pharmacokinetic and pharmacodynamic studies in both cellular and animal models of cancer research.

Research Area

Cardiovascular Research, Metabolism Research, Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 404844-02-6
• MW: 479.576
• Purity: 98.60% (May vary between batches)
• Formula: C₂₈H₂₉N₇O
• SMILES: O=C(NC1=CC=C(C)C(NC2=NC=CC(C3=CC=CN=C3)=N2)=C1)C4=CC=C(CN5CCNCC5)C=C4
• Target: Bcr-Abl,c-Kit,Drug Metabolite,PDGFR
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (6.88 mM);DMSO:99 mg/mL (206.43 mM)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

BcrAbl, c-Kit, cKit, DrugMetabolite, Drug Metabolite, N Desmethyl imatinib, Imatinib metabolite N-Desmethyl imatinib, Imatinib, Norimatinib, inhibit, Inhibitor, NDesmethyl imatinib, N-Desmethyl imatinib, PDGFR, v-Abl

Compound Identifiers

PubChem CID

9869737