N-Desmethyl imatinib

SKU: orb1309548

Description

N-Desmethyl imatinib is the primary active metabolite of the tyrosine kinase inhibitor Imatinib. It retains activity against targets such as c-Kit, Abl, and PDGFR, making it a relevant compound for pharmacokinetic and pharmacodynamic studies in both cellular and animal models of cancer research.

Research Area

Cardiovascular Research, Metabolism Research, Signal Transduction

Key Properties

• CAS Number: 404844-02-6
• MW: 479.58
• Purity: 98.60%
• Formula: C₂₈H₂₉N₇O
• SMILES: Cc1ccc(NC(=O)c2ccc(CN3CCNCC3)cc2)cc1Nc1nccc(n1)-c1cccnc1
• Target: Drug Metabolite,Bcr-Abl,PDGFR,c-Kit
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (6.88 mM);DMSO:99 mg/mL (206.43 mM)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

BcrAbl, c-Kit, cKit, DrugMetabolite, Drug Metabolite, N Desmethyl imatinib, Imatinib metabolite N-Desmethyl imatinib, Imatinib, Norimatinib, inhibit, Inhibitor, NDesmethyl imatinib, N-Desmethyl imatinib, PDGFR, v-Abl

Compound Identifiers

PubChem CID

9869737