N-desmethyl Enzalutamide

SKU: orb1307019

Description

N-desmethyl Enzalutamide is the pharmacologically active primary metabolite of the androgen receptor antagonist Enzalutamide. It exhibits comparable potency and plasma exposure, making it a critical subject for in vitro binding studies and in vivo pharmacological research on prostate cancer models.

Research Area

Metabolism Research

Key Properties

• CAS Number: 1242137-16-1
• MW: 450.41
• Purity: 99.74% (May vary between batches)
• Formula: C₂₀H₁₄F₄N₄O₂S
• SMILES: CC1(C)N(C(=S)N(C1=O)c1ccc(C#N)c(c1)C(F)(F)F)c1ccc(C(N)=O)c(F)c1
• Target: Androgen Receptor
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.44 mM);DMSO:50 mg/mL (111.01 mM)

Bioactivity

• In Vivo:
  N-desmethyl Enzalutamide, an active metabolite contributing to the clinical effects of Enzalutamide, circulates at similar plasma concentrations to Enzalutamide. The pharmacologically inactive carboxylic acid metabolite circulates at approximately 25% lower plasma concentrations than Enzalutamide .

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

AndrogenReceptor, Androgen-receptor, Androgen Receptor, Androgen receptor, Inhibitor, N desmethyl Enzalutamide, inhibit, N-desmethyl MDV3100, N-desmethyl MDV-3100, Ndesmethyl Enzalutamide, N-desmethyl Enzalutamide, N-desmethyl MDV 3100

Compound Identifiers

PubChem CID

70678916