N-Desethylsunitinib hydrochloride

SKU: orb1309373

Description

N-Desethylsunitinib hydrochloride is the primary active metabolite of the anticancer drug sunitinib. It functions as a potent ATP-competitive inhibitor targeting VEGFR, PDGFRβ, and KIT tyrosine kinases, making it a valuable tool compound for in vitro and in vivo angiogenesis and oncology research.

Research Area

Cardiovascular Research, Metabolism Research, Signal Transduction

Key Properties

• CAS Number: 1261432-05-6
• MW: 406.88
• Purity: 99.42%
• Formula: C₂₀H₂₄ClFN₄O₂
• SMILES: O=C1C(C2=CC(F)=CC=C2N1)=CC(NC(C)=C3C(NCCNCC)=O)=C3C.Cl
• Target: PDGFR,PDE,c-Kit,VEGFR
• Solubility: DMSO:9 mg/mL (22.12 mM)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

cKit, N Desethylsunitinib hydrochloride, KIT, PDGFRβ, NDesethylsunitinib hydrochloride, N-Desethylsunitinib Hydrochloride, VEGFR

Compound Identifiers

PubChem CID

75038687