N-Desethyl Sunitinib

SKU: orb1709068

Description

Sunitinib is an oral multi-tyrosine kinase inhibitor targeting VEGFR, PDGFR, KIT, and FLT3, used in advanced renal cell carcinoma. Its primary active metabolite, N-Desethyl Sunitinib (SU012662), is formed via CYP3A4 metabolism and is utilized in pharmacokinetic and efficacy studies both in vitro and in vivo.

Research Area

Cardiovascular Research, Metabolism Research, Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 356068-97-8
• MW: 370.42
• Formula: C₂₀H₂₃FN₄O₂
• SMILES: C(=C\1/C=2C(NC1=O)=CC=C(F)C2)\C3=C(C)C(C(NCCNCC)=O)=C(C)N3
• Target: VEGFR,PDGFR,FLT,c-Kit,Drug Metabolite
• Solubility: DMSO:4 mg/mL (10.8 mM)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

SU11662, SU-11662, SU12662, SU-12662, SU 11662, SU 12662, PDGFRβ, VEGFR, NDesethyl Sunitinib, N-Desethyl Sunitinib, N Desethyl Sunitinib, Inhibitor, KIT, inhibit, cKit

Compound Identifiers

PubChem CID

10292573