N-Desethyl Sunitinib

SKU: orb1709068

Description

Sunitinib is an oral multi-tyrosine kinase inhibitor targeting VEGFR, PDGFR, KIT, and FLT3, used in advanced renal cell carcinoma. Its primary active metabolite, N-Desethyl Sunitinib (SU012662), is formed via CYP3A4 metabolism and is utilized in pharmacokinetic and efficacy studies both in vitro and in vivo.

Research Area

Cardiovascular Research, Metabolism Research, Signal Transduction

Key Properties

• CAS Number: 356068-97-8
• MW: 370.42
• Formula: C₂₀H₂₃FN₄O₂
• SMILES: C(=C\1/C=2C(NC1=O)=CC=C(F)C2)\C3=C(C)C(C(NCCNCC)=O)=C(C)N3
• Target: VEGFR,PDGFR,FLT,c-Kit,Drug Metabolite
• Solubility: DMSO:4 mg/mL (10.8 mM)

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

SU11662, SU-11662, SU12662, SU-12662, SU 11662, SU 12662, PDGFRβ, VEGFR, NDesethyl Sunitinib, N-Desethyl Sunitinib, N Desethyl Sunitinib, Inhibitor, KIT, inhibit, cKit

Compound Identifiers

PubChem CID

10292573