N-Descyclopropanecarbaldehyde Olaparib

SKU: orb1909117

Description

N-Descyclopropanecarbaldehyde Olaparib is a functionalized analogue of the PARP inhibitor Olaparib, incorporating a DOTA chelator. This derivative serves as a CRBN-binding ligand for constructing PROTAC molecules, such as dual-targeting EGFR/PARP degraders, and is designed for radiolabeling with F-18 or fluorophores to enable tumor visualization via PET or optical imaging in preclinical research.

Research Area

Epigenetics & Chromatin, Molecular Biology, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 763111-47-3
• MW: 366.389
• Formula: C₂₀H₁₉FN₄O₂
• SMILES: O=C1NN=C(CC2=CC=C(F)C(C(N3CCNCC3)=O)=C2)C4=C1C=CC=C4
• Target: E3 Ligase Ligand-Linker Conjugates,PARP,Ligands for Target Protein for PROTAC,Others

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

11726399