N-butyl Lithocholic Acid

SKU: orb2815798

Description

This research-grade small molecule, N-butyl Lithocholic acid, is a derivative of lithocholic acid. When formulated into lipid nanoparticles for mRNA vaccine delivery, such as those encoding hemagglutinin, it demonstrates a reduced toxicity profile in mouse models compared to cholesterol-containing LNPs, showing lower cardiotoxicity and hepatosplenic effects. This makes it a valuable tool for investigating safer lipid nanoparticle systems in vaccinology and gene delivery research.

Research Area

Metabolism Research

Key Properties

• CAS Number: 135013-42-2
• MW: 432.68
• Formula: C₂₈H₄₈O₃
• SMILES: C[C@@]12[C@]([C@]3([C@@]([C@]4(C)[C@](CC3)(C[C@H](O)CC4)[H])(CC1)[H])[H])(CC[C@@]2([C@@H](CCC(OCCCC)=O)C)[H])[H]
• Target: Endogenous Metabolite

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

15056430