N-Butanoyl-L-homoserine lactone

SKU: orb1307345

Description

N-Butanoyl-L-homoserine lactone (C4-HSL) is a cleavable linker for antibody-drug conjugates and a key Pseudomonas aeruginosa quorum-sensing molecule. Its application in research includes studying and inhibiting biofilm formation in vitro, offering a strategy to disrupt bacterial communication and virulence.

Research Area

Infectious Disease & Virology, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 67605-85-0
• MW: 171.194
• Purity: 99.87% (May vary between batches)
• Formula: C₈H₁₃NO₃
• SMILES: CCCC(N[C@@H]1C(OCC1)=O)=O
• Target: ADC Linker,PROTAC Linker,Antibacterial
• Solubility: DMSO:30 mg/mL (175.24 mM);H2O:30 mg/mL (175.24 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (11.68 mM)

Bioactivity

• In Vitro:
  ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Cleavable, cleavable, conjugates, ADC Linkers, ADC Linker, ADCLinker, ADC, Antibody-drug conjugates linkers, antibody-drug, antibacterial, Bacterial, biofilm, C4-HSL, N Butanoyl L homoserine lactone, Inhibitor, inhibit, NButanoylLhomoserine lactone, N-Butanoyl-L-homoserine lactone, N-Butyryl-L-homoserine lactone

Compound Identifiers

PubChem CID

10130163