N-a-Tosyl-L-lysinyl-chloromethylketone hydrochloride

SKU: orb3134466

Description

N-a-Tosyl-L-lysinyl-chloromethylketone hydrochloride (TLCK hydrochloride) is an irreversible serine protease inhibitor that functions by alkylating the histidine residue at the active site, thus inhibiting trypsin and trypsin-like proteases. It effectively inhibits caspase-3, caspase-6, and caspase-7 with IC50 values of 12.0, 54.5, and 19.3 μM, respectively. Additionally, N-a-Tosyl-L-lysinyl-chloromethylketone hydrochloride induces apoptosis in HL-60 cells and prevents the reduction of mitochondrial transmembrane potential during the apoptosis process.

Research Area

Cell Biology, Protein Biochemistry

Key Properties

• CAS Number: 4238-41-9
• MW: 369.31
• Formula: C₁₄H₂₂Cl₂N₂O₃S
• SMILES: Cl.O=C(CCl)C(NS(=O)(=O)C1=CC=C(C=C1)C)CCCCN
• Target: Caspase,Serine Protease

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Caspase,Serine Protease