ALK5-IN-10

SKU: orb1297850

Description

Compound 12d is a highly effective small molecule inhibitor of ALK5 (TGF-β type I receptor), exhibiting potent activity with a 7 nM IC50. This inhibitor is a valuable research tool for studying TGF-β signaling pathways in both cellular assays and animal models of fibrosis and cancer.

Research Area

Cardiovascular Research, Cell Biology, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 1352608-94-6
• MW: 460.33
• Purity: 99.94% (May vary between batches)
• Formula: C₂₂H₁₈BrN₇
• SMILES: C(NC1=C(Br)C=CC=C1)C=2NC(=C(N2)C=3N=C(C)C=CC3)C4=CN5C(C=C4)=NC=N5
• Target: ALK,TGF-beta/Smad
• Solubility: DMSO:50 mg/mL (108.62 mM)

Bioactivity

• Target IC50:
  TGFβRI:7 nM

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

ALK5, N ((4 ([1,2,4]triazolo[1,5 a]pyridin 6 yl) 5 (6 methylpyridin 2 yl) 1H imidazol 2 yl)methyl) 2 bromoaniline, N((4([1,2,4]triazolo[1,5a]pyridin6yl)5(6methylpyridin2yl)1Himidazol2yl)methyl)2bromoaniline

Compound Identifiers

PubChem CID

54766325