MZ 1

SKU: orb1301791

Description

MZ-1 is a PROTAC-based small molecule that selectively degrades the BRD4 protein. It serves as a chemical probe for studying BRD4 function in oncology and transcriptional regulation research, with utility demonstrated in both cellular and in vivo models.

Research Area

Epigenetics & Chromatin, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1797406-69-9
• MW: 1002.64
• Purity: 99.31%
• Formula: C₄₉H₆₀ClN₉O₈S₂
• SMILES: CC=1C2=C(N3C([C@H](CC(NCCOCCOCCOCC(N[C@H](C(=O)N4[C@H](C(NCC5=CC=C(C=C5)C6=C(C)N=CS6)=O)C[C@@H](O)C4)C(C)(C)C)=O)=O)N=C2C7=CC=C(Cl)C=C7)=NN=C3C)SC1C
• Target: PROTACs,Epigenetic Reader Domain
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (1.99 mM);DMSO:127.5 mg/mL (127.16 mM)

Bioactivity

• Target IC50:
  BRD4 BD1/2:382/120 nM (Kd)|BRD2 BD1/2:307/228 nM (Kd)|BRD3 BD1/2:119/115 nM (Kd)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

degradation, Degrader, cells, BRD4, inhibit, Inhibitor, LS174t, MZ1, MZ-1, MZ 1, Epigenetic Reader Domain, EpigeneticReaderDomain, protein, PROTACs, selective

Compound Identifiers

PubChem CID

122201421