MyD88-IN-3

SKU: orb3173506

Description

MyD88-IN-3 is an orally active, selective MyD88 inhibitor that specifically targets the TIR domain of MyD88 (KD= 28.5 μM). It prevents MyD88 self-aggregation and its interaction with TLRs, thereby suppressing the activation of the MAPK and NF-κB pathways. MyD88-IN-3 exhibits significant anti-inflammatory effects and effectively alleviates symptoms of acute lung injury in CLP (cecal ligation and puncture) and LPS (lipopolysaccharide)-induced ALI models. This compound is valuable for ALI research.

Research Area

Immunology & Inflammation, Signal Transduction

Key Properties

• Target: JNK,MyD88,p38 MAPK,NF-κB,TLR

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

JNK,MyD88,p38 MAPK,NF-κB,TLR