Mycothiazole

SKU: orb3141555

Description

Mycothiazole is an inhibitor of mitochondrial electron transport chain (ETC) complex I. It exhibits cytotoxicity in cancer cells Huh7 (IC50 of 55.8 μM), U87, and MCF7. In Huh7 cells, Mycothiazole induces apoptosis (apoptosis). Additionally, Mycothiazole extends the lifespan of C. elegans by modulating transcription factors ATFS-1 and HSF1, which are associated with the unfolded protein response (UPR) and heat shock response (HSR).

Research Area

Metabolism Research

Key Properties

• CAS Number: 114582-75-1
• MW: 404.57
• Formula: C₂₂H₃₂N₂O₃S
• SMILES: C([C@H](C/C=C\C(CCNC(OC)=O)=C)O)(C)(C)C1=NC(C/C=C\CC=C)=CS1
• Target: Mitochondrial Metabolism

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Mitochondrial Metabolism