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MYCi975
Catalog Number: orb1219642
| Catalog Number | orb1219642 |
|---|---|
| Category | Small Molecules |
| Description | MYCi975 is an orally active inhibitor of MYC.MYCi975 inhibits P493-6, MV411,SK-N-B2 cells viability in an MYC-dependent manner(IC50s of 3.7, 3.9, 6.4 μM, respectively).The initial lead, MYC inhibitor 361 (MYCi361), suppressed in vivo tumor growth in mice, increased tumor immune cell infiltration, upregulated PD-L1 on tumors, and sensitized tumors to anti-PD1 immunotherapy. However, 361 demonstrated a narrow therapeutic index. |
| Target | MYC |
| Purity | > 98% (HPLC) |
| MW | 561.3 |
| CAS Number | 2289691-01-4 |
| Formula | C25H16Cl2F6N2O2 |
| Storage | Storage temperature: -20°C. Stability: ≥ 2 years |
| Note | For research use only |
MYCi975 [orb1709073]
99.58%
[2289691-01-4]
561.3
C25H16Cl2F6N2O2
50 mg, 25 mg, 10 mg, 5 mg, 1 mg, 1 ml x 10 mM (in DMSO)
