MX69

SKU: orb1227173

Description

A novel specific inhibitor of MDM2 inhibitor with Kd of 2.75 uM; induces ubiquitination of endogenous MDM2, results in activation of p53 and inhibition of XIAP, and induces cell apoptosis and death in cancer cells; shows significant apoptotic and anti-proliferative effects on MDM2-expressing cancer cells both in vitro and in vivo, with minimal inhibitory effect on normal human hematopoiesis.

Key Properties

• CAS Number: 1005264-47-0
• MW: 474.57134
• Purity: >98% (HPLC)
• Formula: C₂₇H₂₆N₂O₄S
• SMILES: O=S(C1=CC2=C(NC(C3=CC=C(C(O)=O)C=C3)C4C2C=CC4)C=C1)(NC5=C(C)C(C)=CC=C5)=O
• Target: MDM2-p53
• Solubility: DMSO: ≥ 30 mg/mL

Bioactivity

• In Vivo:
  MX69-induced MDM2 downregulation results in activation of p53 which contributes to inhibition of cancer cell proliferation In vivo.
• In Vitro:
  MX69 blocks the MDM2 protein-XIAP RNA interaction, leading to MDM2 degradation. MX69 shows minimal inhibitory effect on normal human hematopoiesis in vitro and is very well tolerated in animal models. MX69-induced MDM2 down regulation results not only in inhibition of XIAP expression, but also in activation of p53, which contributes to cancer cell apoptosis in vitro.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

MX 69 | MX-69

Quick Database Links

Gene Symbol

MDM2-p53