MU876

SKU: orb3173310

Description

MU876 (Compound 32) is an MUS81 inhibitor with an IC50 of 0.5 μM. It effectively inhibits MUS81-dependent homologous recombination (HR) and break-induced replication (BIR) pathways. MU876 enhances the sensitivity of cancer cells to DNA-damaging agents like Cisplatin by impairing their ability to repair DNA damage. This compound is applicable in cancer chemotherapy research.

Research Area

Cell Biology

Key Properties

• CAS Number: 1208829-24-6
• MW: 438.4381
• Formula: C₂₄H₁₈N₆O₃
• SMILES: CC1=CC(=O)NC(=N1)N1N=C(C=C1NC(=O)C1=NOC(=C1)C1=CC=CC=C1)C1=CC=CC=C1
• Target: Endonuclease

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Endonuclease