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MTX-216

SKU: orb3028873

Description

MTX-216 is an ATP-competitive inhibitor targeting both PI3K and EGFR. It simultaneously inhibits Ki-67 and ribosomal S6 phosphorylation, inducing apoptosis in NF1LOF cells. Additionally, MTX-216 suppresses SYK kinase activity with an IC50 of 281 nM. This compound is applicable for melanoma research.

Research Area

Cardiovascular Research, Cell Biology, Signal Transduction

Images & Validation

Key Properties

CAS Number1952236-19-9
MW502.348
FormulaC22H14Cl2FN5O2S
SMILESN#CC=1C=NC2=CC=C(C=C2C1NC3=CC=C(F)C(Cl)=C3)C=4C=NC(Cl)=C(C4)NS(=O)(=O)C
TargetSyk,EGFR,PI3K,Apoptosis

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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Protocol Information