MTX-211

SKU: orb1225788

Description

A first-in-class, highly selective, dual inhibitor of PI3K and EGFR kinases with demonstrated in vivo anticancer activity against multiple KRAS mutant colorectal tumors; shows limited off-target toxicity and a broad therapeutic window.

Key Properties

• CAS Number: 1952236-05-3
• MW: 478.323
• Purity: >98% (HPLC)
• Formula: C₂₀H₁₄Cl₂FN₅O₂S
• SMILES: CS(=O)(NC1=CC(C2=CC3=C(NC4=CC=C(F)C(Cl)=C4)N=CN=C3C=C2)=CN=C1Cl)=O
• Target: PI3K
• Solubility: DMSO: ≥100 mg/mL （ < 1 mg/ml refers to the product slightly soluble or insoluble )

Bioactivity

• In Vitro:
  MTX-211 (MOL211) has inhibitory activity for both EGFR and PI3K Alpha with IC50 values of <100 nM.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

MTX 211

Quick Database Links

Gene Symbol

PI3K