mTOR inhibitor 9f

SKU: orb1819214

Description

The compound 9f is a potent and selective mTOR inhibitor, exhibiting IC50 values of 1.25 nM for mTOR and 82 nM for PI3Kα. It serves as a valuable chemical probe for studying mTOR signaling in cancer research and has demonstrated utility in both cellular and in vivo models of tumor growth.

Research Area

Signal Transduction

Key Properties

• CAS Number: 1144075-42-2
• MW: 457.55
• Purity: 99.18% (May vary between batches)
• Formula: C₂₅H₂₃N₅O₂S
• SMILES: N(C(NC1=CC=CC=C1)=O)C2=CC=C(C3=NC(=C4C(=N3)C=CS4)N5CC6OC(C5)CC6)C=C2
• Target: mTOR,PI3K
• Solubility: DMSO:45 mg/mL (98.35 mM)

Bioactivity

• Target IC50:
  PI3Kα:82nM|mTOR:1.25nM
• In Vitro:
  mTOR inhibitor 9f inhibits the growth of LNCaP cell with IC50 of 140nM.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

1(4(4(8oxa3azabicyclo[3.2.1]octan3yl)thieno[3,2d]pyrimidin2yl)phenyl)3phenylurea, mTOR inhibitor 9f, mTOR, PI3Kα

Compound Identifiers

PubChem CID

46227625