mTOR inhibitor 9e

SKU: orb1819211

Description

The compound 9e is a potent and selective mTOR inhibitor, exhibiting an IC50 of 0.68 nM for mTOR while showing significantly lower activity against PI3Kα (IC50 = 1359 nM). This selectivity profile makes it a valuable chemical probe for studying mTOR-dependent signaling pathways in cancer research and cellular biology, applicable in both in vitro and in vivo experimental models.

Research Area

Signal Transduction

Key Properties

• CAS Number: 1144075-40-0
• MW: 421.52
• Purity: 98.84%
• Formula: C₂₂H₂₃N₅O₂S
• SMILES: N(C(NC1CC1)=O)C2=CC=C(C3=NC(=C4C(=N3)C=CS4)N5CC6OC(C5)CC6)C=C2
• Target: PI3K,mTOR
• Solubility: DMSO:1 mg/mL (2.37 mM)

Bioactivity

• Target IC50:
  mTOR:0.68nM|PI3Kα:1359nM
• In Vitro:
  mTOR inhibitor 9e inhibits the growth of LNCaP cell with IC50 of 40nM.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

1(4(4(8oxa3azabicyclo[3.2.1]octan3yl)thieno[3,2d]pyrimidin2yl)phenyl)3cyclopropylurea, mTOR inhibitor 9e, mTOR, PI3Kα

Compound Identifiers

PubChem CID

46227620