mTOR inhibitor 9d

SKU: orb1819213

Description

The small molecule mTOR inhibitor 9d is a potent dual inhibitor of mTOR and PI3K kinases, exhibiting an mTOR IC50 of 0.31 nM. It is utilized in cancer research, including studies on leukemia and solid tumors, with applications in both in vitro cellular assays and in vivo xenograft models.

Research Area

Signal Transduction

Key Properties

• CAS Number: 1144075-38-6
• MW: 425.5
• Purity: 99.08%
• Formula: C₂₁H₂₃N₅O₃S
• SMILES: N(C(NCCO)=O)C1=CC=C(C2=NC(=C3C(=N2)C=CS3)N4CC5OC(C4)CC5)C=C1
• Target: mTOR,PI3K
• Solubility: DMSO:45 mg/mL (105.76 mM)

Bioactivity

• Target IC50:
  mTOR:0.31 nM|Phosphatidylinositol 3-kinase PIK3CA:324 nM|LNCaP cells:180 nM
• In Vitro:
  mTOR inhibitor 9d (compound 9d) inhibitory concentration against the proliferation of human prostate cancer LNCaP cell line by cellular proliferation assay with IC50 is 180 nM.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

mTOR, mTOR inhibitor 9d, 1(2hydroxyethyl)3{4[4(8oxa3azabicyclo[3.2.1]oct3yl)thieno[3,2d]pyrimidin2yl]phenyl}urea, PI3K

Compound Identifiers

PubChem CID

46227615