mTOR inhibitor 9c

SKU: orb1819209

Description

mTOR inhibitor 9c is a highly selective mTOR inhibitor, exhibiting potent activity against mTOR with an IC50 of 0.7 nM while showing significantly weaker inhibition of PI3Kα (IC50 = 825 nM). This selectivity profile makes it a valuable chemical probe for studying mTOR-dependent signaling pathways in cancer research and cell biology, applicable in both in vitro and in vivo experimental models.

Research Area

Signal Transduction

Key Properties

• CAS Number: 1144075-36-4
• MW: 427.5
• Purity: 99.23%
• Formula: C₂₁H₂₂FN₅O₂S
• SMILES: N(C(NCCF)=O)C1=CC=C(C2=NC(=C3C(=N2)C=CS3)N4CC5OC(C4)CC5)C=C1
• Target: PI3K,mTOR
• Solubility: DMSO:60 mg/mL (140.35 mM)

Bioactivity

• Target IC50:
  mTOR:0.7nM|PI3Kα:825nM
• In Vitro:
  mTOR inhibitor 9c inhibits the growth of LNCaP cell with IC50 of 87nM.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

1(2fluoroethyl)3{4[4(8oxa3azabicyclo[3.2.1]oct3yl)thieno[3,2d]pyrimidin2yl]phenyl}urea, mTOR inhibitor 9c, mTOR, PI3Kα

Compound Identifiers

PubChem CID

46227600