mTOR inhibitor 9b

SKU: orb1819212

Description

mTOR inhibitor 9b is a potent dual inhibitor of mTOR and PIK3CA with IC50 values of 0.76 nM and 1.262 µM, respectively. It exhibits anticancer activity and is a useful research tool for studying various cancers, including leukemia and solid tumors, in both in vitro and in vivo experimental models.

Research Area

Signal Transduction

Key Properties

• CAS Number: 1144075-34-2
• MW: 409.5
• Purity: 99.89%
• Formula: C₂₁H₂₃N₅O₂S
• SMILES: N(C(NCC)=O)C1=CC=C(C2=NC(=C3C(=N2)C=CS3)N4CC5OC(C4)CC5)C=C1
• Target: mTOR,PI3K
• Solubility: DMSO:15 mg/mL (36.63 mM)

Bioactivity

• Target IC50:
  PIK3CA:1.262 µM

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

mTOR, mTOR inhibitor 9b, 1ethyl3{4[4(8oxa3azabicyclo[3.2.1]oct3yl)thieno[3,2d]pyrimidin2yl]phenyl}urea

Compound Identifiers

PubChem CID

46227599